Rabbit Secondary Antibodies
ABclonal Technology 488 Rabbit anti-Human CD116
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2 a cytokine which controls the production differentiation and function of granulocytes and macrophages The encoded protein is a member of the cytokine family of receptors This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes Multiple transcript variants encoding different isoforms have been found for this gene with some of the isoforms being membrane-bound and others being soluble
Jackson Immuno Research Labs Cy3-AffiniPure F(ab')2 Fragment Rabbit Anti-Human IgM Fc5µ Fragment Specific
Cy3-AffiniPure F(ab')2 Fragment Rabbit Anti-Human IgM Fc5µ Fragment Specific
ABclonal Technology 594 Rabbit anti-Human MERTK
This gene is a member of the MER AXL TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains two Ig-like C2-type (immunoglobulin-like) domains and one tyrosine kinase domain Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP)
ABclonal Technology 647 Rabbit anti-Human FceR1a
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules mediators such as histamine that are responsible for allergy symptoms are released This receptor is comprised of an alpha subunit a beta subunit and two gamma subunits The protein encoded by this gene represents the alpha subunit
ABclonal Technology 594 Rabbit anti-Human FATP1
Enables biotin transmembrane transporter activity efflux transmembrane transporter activity and long-chain fatty acid transporter activity Involved in several processes including carboxylic acid transmembrane transport glycerophospholipid biosynthetic process and lipid transport across blood-brain barrier Located in membrane Part of plasma membrane
ABclonal Technology 610 Rabbit anti-Human IgD
IgD is the major antigen receptor isotype on the surface of most peripheral B-cells where it is coexpressed with IgM The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases
ABclonal Technology 700 Rabbit anti-Human IgD
IgD is the major antigen receptor isotype on the surface of most peripheral B-cells where it is coexpressed with IgM The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases
ABclonal Technology 594 Rabbit anti-Human CD38
The protein encoded by this gene is a non-lineage-restricted type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5 -diphosphate-ribose an intracellular calcium ion mobilizing messenger The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein This protein has an N-terminal cytoplasmic tail a single membrane-spanning domain and a C-terminal extracellular region with four N-glycosylation sites Crystal structure analysis demonstrates that the functional molecule is a dimer with the central portion containing the catalytic site It is used as a prognostic marker for patients with chronic lymphocytic leukemia Alternative splicing results in multiple transcript variants
ABclonal Technology 700 Rabbit anti-Human IgD
IgD is the major antigen receptor isotype on the surface of most peripheral B-cells where it is coexpressed with IgM The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases
ABclonal Technology PE Rabbit anti-Human CD153 mAb
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family This cytokine is a ligand for TNFRSF8 CD30 which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch This cytokine was shown to enhance cell proliferation of some lymphoma cell lines while to induce cell death and reduce cell proliferation of other lymphoma cell lines The pleiotropic biologic activities of this cytokine on different CD30 lymphoma cell lines may play a pathophysiologic role in Hodgkin s and some non-Hodgkin s lymphomas Two transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 488 Rabbit anti-Human GPRC5D
The protein encoded by this gene is a member of the G protein-coupled receptor family however the specific function of this gene has not yet been determined
ABclonal Technology 647 Rabbit anti-Human CD68
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages It is a member of the lysosomal endosomal-associated membrane glycoprotein (LAMP) family The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins The protein is also a member of the scavenger receptor family Scavenger receptors typically function to clear cellular debris promote phagocytosis and mediate the recruitment and activation of macrophages Alternative splicing results in multiple transcripts encoding different isoforms
ABclonal Technology PE Rabbit anti-Human IL-2 mAb
This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4 IL7 IL9 IL15 IL21 erythropoietin and thrombopoietin The protein encoded by this gene is a secreted cytokine produced by activated CD4 and CD8 T lymphocytes that is important for the proliferation of T and B lymphocytes The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7 The expression of this gene in mature thymocytes is monoallelic which represents an unusual regulatory mode for controlling the precise expression of a single gene The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease which suggests an essential role of this gene in the immune response to antigenic stimuli
ABclonal Technology 488 Rabbit anti-Human CD33
CD33 a type I transmembrane protein is a sialic acid-binding Ig-like lectin (Siglec-3) of the Ig superfamily and human CD33 binds preferentially to alpha-2 6-linked sialic acid Upon binding to its ligands CD33 transduces an inhibitory signaling through the immunoreceptor tyrosine-based inhibitory motif (ITIM) in its intracellular domain inhibiting cellular function such as phagocytosis In addition CD33 is also involved in other processes such as adhesion Due to its exclusive expression on hematopoietic cells particularly the myeloid lineage and their progenitors CD33 has been actively pursued as a therapeutic target against acute myeloid leukemia (AML) CD33 may also be involved in Alzheimer s Disease
ABclonal Technology 647 Rabbit anti-Human EGFR
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily This protein is a receptor for members of the epidermal growth factor family EGFR is a cell surface protein that binds to epidermal growth factor Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation Mutations in this gene are associated with lung cancer